About Diabetes Medications

March 15, 2012 at 9:00 am | Posted in Health | 1 Comment
Tags: , , , , ,

By Deanna Wrubleski, Pharmacy StudentDeanna W
University of Rhode Island

The list of medications used to treat Diabetes is long, and is likely to grow even longer as new medications are developed. As a person with Type II Diabetes, you may be on one, two, or even three of these medications (or more!) and it’s easy to become overwhelmed. It’s good to know how your medications work and what they’re doing to help lower your blood glucose.

Diabetes medications work in four major ways:

  1. Increase insulin production and release from the pancreas
  2. Increase insulin sensitivity
  3. Decrease glucose made by the liver
  4. Slow digestion of carbohydrates into glucose

Medications that work by increasing the insulin made and released by the pancreas include glipizide (Glucotrol), glyburide (Diabeta), nateglinide (Starlix), repaglinide (Prandin), sitagliptan (Januvia), exanatide (Byetta), and liraglutide (Victoza). Since they increase insulin, these medications can cause hypoglycemia as a side effect.  To be on the safe side, make sure you recognize the symptoms of hypoglycemia and know how to treat it.  Over time, these medications may stop working as well as they once did.  After years of making large amounts of insulin to make up for the body’s resistance, the cells in the pancreas become overworked and the pancreas slowly loses its ability to make insulin.

Medications that work by increasing insulin sensitivity include metformin (Glucophage), pioglitazone (Actos), and rosiglitazone (Avandia).  Basically, these medications make the insulin the body already produces work better. People with Type II Diabetes actually produce more insulin than the average person, but resistance causes the insulin to have less of an effect. That is why medications like these are useful for lowering blood glucose.

Medications that work by decreasing the glucose made by the liver include metformin (Glucophage), sitagliptan (Januvia), exanatide (Byetta), and liraglutide (Victoza). If you were starving without any food, it would be good for your liver to make glucose, since your brain needs it to survive. But it’s unnecessary (and even harmful) for the liver to do this if your blood glucose is already high. So for people with Diabetes, telling the liver to “slow down” making glucose is beneficial.

Finally, the two medications that slow the digestion of carbohydrates into glucose are acarbose (Precose) and miglitol (Glyset). Slowing down the digestion of carbohydrates means less glucose is absorbed, which helps prevent a big jump in blood sugar after eating. Keep in mind, though, that these medications only work when taken with a meal, and shouldn’t be taken if a meal is skipped. Also, people taking these medications should always have glucose tablets on hand to treat hypoglycemia. Sucrose, which is what table sugar and most sugary snacks and beverages are made with, won’t treat hypoglycemia in people taking these medications as sucrose is a carbohydrate that still has to be broken down into glucose to be absorbed.

1 Comment »

RSS feed for comments on this post. TrackBack URI

  1. […] lower dose of medications you still require. Many medications have the potential for side effects; diabetes medications are no different. Weight gain IS a possible side effect of insulin, but it may also happen with […]


Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s


Entries and comments feeds.

%d bloggers like this: